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Selumetinib in Children with Inoperable Plexiform Neurofibromas

April 22, 2020

N Engl J Med 2020; 382:1430-1442 DOI: 10.1056/NEJMoa1912735 List of authors. Andrea M. Gross, M.D., Pamela L. Wolters, Ph.D., Eva Dombi, M.D., Andrea Baldwin, P.N.P., Patricia Whitcomb, R.N., Michael J. Fisher, M.D., Brian Weiss, M.D., […]

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Selumetinib: The First Effective Treatment for Plexiform Neurofibromas

April 22, 2020

A young patient with NF1 who was treated at NCI gathers with her mother and members of NCI’s Pediatric Oncology Branch. Credit: National Institutes of Health Over 30 years of NCI-led and NCI-supported research culminated […]

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Induced pluripotent stem cells have been generated for the first time from tumor cells in order to study therapies for tumors developed in patients with hereditary diseases with predisposition to cancer

February 13, 2019

Induced pluripotent stem cells have been generated for the first time from tumor cells in order to study therapies for tumors developed in patients with hereditary diseases with predisposition to cancer  The study focuses on […]

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Data made available for Research Tools that Accelerate Development of Therapies for Neurofibromatosis Type 1 Plexiform Neurofibromas

October 22, 2018

For Release: October 2018 Development of therapies for human disease remains dependent on well-characterized and validated model systems.  Slow growing histologically benign tumors such as neurofibromas are challenging to grow in typical culture conditions.  As […]

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Data made available for a 3D model of Neurofibromatosis Type 1 Plexiform Neurofibromas

October 22, 2018

For Release: October 2018 Development of therapies for human disease remains dependent on well-characterized and validated model systems for pre-clinical therapeutic testing. Most in vitro drug testing is performed on cells growing in two dimensions […]

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Two New Clinician-Scientists Chosen for Neurofibromatosis Award, Research Support

July 13, 2018

Author: Cathy Gara. July 2018–The Neurofibromatosis Therapeutic Acceleration Program (NTAP) at the Johns Hopkins University School of Medicine is proud to announce that Dr. Shruti Garg, of the University of Manchester, and Dr. Ina Ly, […]

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Funding Available for Neurofibromatosis Research from the Department of Defense – Congressionally Directed Medical Research Programs

July 13, 2018

The FY18 Neurofibromatosis Research Program (NFRP) is accepting applications for research projects. Applications to the Fiscal Year 2018 (FY18) Neurofibromatosis Research Program (NFRP) are being solicited for the Defense Health Agency (DHA) J9, Research and Development […]

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New Research Tools Available in the Search for Therapies for Neurofibromatosis Type 1 Plexiform Neurofibromas

June 17, 2018

New Research Tools Available in the Search for Therapies for Neurofibromatosis Type 1 Plexiform Neurofibromas By Cathy Gara | For Release: June 15, 2018 Plexiform neurofibromas affect up to 50 percent of people with neurofibromatosis […]

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NTAP announces Dr. Angela Hirbe (Washington University) and Dr. Ping Chi (Memorial Sloan Kettering Cancer Center) have been selected as the 2017 recipients of the Francis S. Collins Scholars Award in Neurofibromatosis Clinical and Translational Research

May 13, 2018

The Neurofibromatosis Therapeutic Acceleration Program (NTAP) at The Johns Hopkins School of Medicine is proud to announce that Dr. Angela Hirbe (Washington University) and Dr. Ping Chi (Memorial Sloan Kettering Cancer Center) have been selected […]

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NTAP and CTF supported early-phase trial demonstrates shrinkage in pediatric neural tumors

February 6, 2017

Bethesda, MD (December 28, 2016) NCI Press Release: In an early-phase clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 (NF1) and plexiform neurofibromas, tumors of the […]

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