Mouse Models

Neurofibromatosis Therapeutic Acceleration Program (NTAP) supports programs that foster collaboration and encourage the open and timely sharing of results. The reagents and knowledge that are generated in our programs are made available to the neurofibromatosis community to ensure discoveries are advanced as quickly as possible.

MOUSE MODELS:

DhhCre-Nf1fl/fl     

  • Uses:  Therapeutics and gene expression analysis; a key model used as part of the NFTC collaboration.
  • Source: Nancy Ratner, Ph.D. (Nancy.Ratner@cchmc.org)

Krox20;Nf1flox/−

  • Uses: Therapeutics and dosing schedules and investigating patterns of resistance;  a key model used as part of the NFTC collaboration.
  • Source: D. Wade Clapp, M.D. (dclapp@iupui.edu)

Transgenic Nf1 Nf1+/-; p53+/-   

  • Uses: Safety, Biomarker therapy; model Dr. Staedtke (one of NTAP’s Francis Collins Scholars) uses for her project evaluating Clostridium Novi for MPNST
  • Source: Karen Cichowski, Ph.D. (kcichowski@rics.bwh.harvard.edu), Tyler Jacks, Ph.D. (tjacks@mit.edu)

Nestin-CreER+; Nf1fl/fl or flox/+

  • Uses: MEK-inhibitor treatment strategy; model that Dr. Bornhorst (one of NTAP’s Francis Collins Scholars) uses in probing the timing of critical events preceding onset of OPG.
  • Source: Yuan Zhu, Ph.D. (yzhu@childrensnational.org)

Nf1-/- ;R26R-LacZ-Luciferase DNSC 

  • Uses: Cells of origin
  • Source: Lu Le, M.D., Ph.D. (Lu.Le@UTSouthwestern.edu)